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Особенности функционального состояния коры надпочечников и щитовидной железы при метаболическом синдроме

Особенности функционального состояния коры надпочечников и щитовидной железы при метаболическом синдроме

Abstract

Цель. Изучить функциональное состояние коры надпочечников и щитовидной железы при метаболическом синдроме (МС). В поперечное рандомизированное исследование включены 186 женщин и 65 мужчин. Изучали содержание в крови кортизола, дегидроэпиандростерона сульфата (ДГЭАС), общего тироксина (Т4), общего трийодтиронина (Т3), тиреотропного гормона у лиц с метаболическим синдромом (критерии IDF, 2005) и без него, а также связь гормональных показателей с параметрами, отражающими компоненты МС. Результаты. МС выявлен у 75 обследуемых из 251 (29,9%). В группе лиц с МС снижены уровни ДГЭАС и Т3 по сравнению с группой без МС, соответственно 1,90±0,18 мкг/мл против 2,37±0,12 мкг/мл (р=0,033) и 2,19±0,26 нмоль/л против 2,59±0,15 нмоль/л (р=0,040). Содержание ДГЭАС обратно коррелировало с систолическим артериальным давлением (r=-0,23, рThe aim. To study the functional state of adrenal cortex and thyroid gland in metabolic syndrome (MS). 186 women and 65 men were included. Blood levels of cortisol, dehydroepiandrosterone sulphate, total thyroxin, total triiodothyronine, thyroid stimulating hormone were studied in subjects with and without metabolic syndrome (IDF test) and their relation with MS components. The results. 75 (29,9%) of the 251 examined patients had MS. In the group with MS the levels of total thyroxin and dehydroepiandrosterone sulphate were decreased to 1,90±0,18 microgram/milliliter vs. 2,37±0,12 microgram/milliliter (р=0,033) in patients without MS and 2,19±0,26 nmol/l vs. 2,59±0,15 nmol/l (р=0,040), respectively. The levels of dehydroepiandrosterone sulphate were inversely correlated with the systolic blood pressure (r=-0,23, р

Keywords

МЕТАБОЛИЧЕСКИЙ СИНДРОМ, ДЕГИДРОЭПИАНДРОСТЕРОНА СУЛЬФАТ, ТРИЙОДТИРОНИН, НАДПОЧЕЧНИКИ, ЩИТОВИДНАЯ ЖЕЛЕЗА

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold