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Journal of Volgograd State Medical University
Article . 2014
Data sources: CyberLeninka - Russian open access scientific library
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Изучение взаимодействия соединения РУ-1205 с анализаторами нейромедиаторных систем

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2014 Russian Publisher:Федеральное государственное бюджетное образовательное учреждение высшего образования «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииJournal:Вестник Волгоградского государственного медицинского университета (issn: 1994-9480, Copyright policy )

Изучение взаимодействия соединения РУ-1205 с анализаторами нейромедиаторных систем

Abstract

The effects of RU-1205 compound with a well-established kappa-opioid activity on the other neurotransmitter systems were studied. The neurochemical mechanisms of the action of RU-1205 were identified. It has been established that the substance under study has no influence on the effects of adrenergic, cholinergic and serotonergic neurotransmitter systems. It has also been determined that RU-1205 reduces fenamic hyperactivity of mice and the number of convulsions induced by bicuculline and picrotoxin.

Изучено влияние соединения РУ-1205 с установленной каппа-опиоидной активностью на другие нейромедиаторные системы, выявлены нейрохимические закономерности его действия. Установлено, что тестируемое вещество не оказывает влияния на эффекты адренергических, серотонинергических и холинергических анализаторов нейромедиаторных систем, снижает фенаминовую гиперактивность мышей и число конвульсивных приступов, вызванных пикротоксином и бикукуллином.

Keywords

АГОНИСТ КАППА-ОПИОИДНЫХ РЕЦЕПТОРОВ,НЕЙРОМЕДИАТОРНЫЕ СИСТЕМЫ ГОЛОВНОГО МОЗГА,ПИКРОТОКСИН,БИКУКУЛЛИН,ФЕНАМИН,KAPPA-AGONIST OPIOID RECEPTORS,NEUROTRANSMITTER SYSTEMS OF THE BRAIN,PICROTOXIN,BICUCULLINE,PHENAMINE

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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