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Место андрогенного дефицита в клиническом портрете современного урологического пациента

Место андрогенного дефицита в клиническом портрете современного урологического пациента

Abstract

In article on the basis of literary given both own clinical supervision and researches applied aspects of androgen deficiency in urological practice are considered. True androgen deficiency’ frequency in man’s population remains precisely not established as decrease in testosterone synthesis is connected not only with the age, but also varieties of other factors, including features of geography of area of residing, presence or absence of other hormonal and metabolic disorders, accompanying somatic comorbidity etc. Results of the newestforeign epidemiological researches of androgen deficiency prevalence worldwide, and also results of the first Russian pilot epidemiological research of androgen deficiency at men prevalence in practice of urologists and doctors of adjacent specialities (Yaroslavl Study, 2013) present in the article. Intime pathogenetic communication of androgen deficiency both the most widespread uroandrological and somatic diseases at men is shown. On the basis of own clinical experience optimum algorithms of complex diagnostics of androgen deficiency at urological patients are offered and also the necessity of inclusion of testosterone preparations for pharmacotherapy of the majority of male urinogenital diseases is shown. The review of indications, contra-indications, estimations of risk factors and preparations for androgen replacement therapy is spent. Features of transdermal forms of testosterone preparations (Аndrogel) are described and the clinical analysis of their present and perspective application within the limits of modern androgen replacement therapy is carried out.

В статье на основе литературных данных и собственных клинических наблюдений и исследований рассматриваются прикладные аспекты андрогенного дефицита в урологической практике. Истинная частота андрогенного дефицита в мужской популяции остается точно не установленной, так как снижение синтеза тестостерона связано не только с возрастом, но и целым рядом других факторов, включая особенности географии района проживания, наличие или отсутствие других гормонально-метаболических нарушений, сопутствующей соматической коморбидности и т. д. В статье представлены результаты новейших зарубежных эпидемиологических исследований частоты распространенности андрогенного дефицита в различных странах мира, а также результаты первого в России пилотного эпидемиологического исследования распространенности андрогенного дефицита у мужчин в практике урологов и врачей смежных специальностей (Ярославское исследование, 2013). Показана тесная патогенетическая связь андрогенного дефицита и наиболее распространенных уроандрологических и соматических заболеваний у мужчин. На основе собственного клинического опыта предложены оптимальные алгоритмы комплексной диагностики андрогенного дефицита у урологических пациентов и показана необходимость включения препаратов тестостерона в фармакотерапию большинства мочеполовых заболеваний у мужчин. Проведен обзор показаний, противопоказаний, оценки факторов риска и препаратов для андрогензаместительной терапии (АЗТ). Описаны особенности накожных форм препаратов тестостерона (Андрогель) и проведен клинический анализ их настоящего и перспективного применения в рамках современной АЗТ.

Keywords

ТЕСТОСТЕРОН,TESTOSTERONE,АНДРОГЕННЫЙ ДЕФИЦИТ,ANDROGEN DEFICIENCY,ЭПИДЕМИОЛОГИЯ,EPIDEMIOLOGY,ДИАГНОСТИКА,DIAGNOSTICS,УРОЛОГИЧЕСКИЕ ЗАБОЛЕВАНИЯ,UROLOGICAL DISEASES,АНДРОГЕНЗАМЕСТИТЕЛЬНАЯ ТЕРАПИЯ,ANDROGEN REPLACEMENT THERAPY,АНДРОГЕЛЬ,ANDROGEL

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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