publication . Article . 2012

Substance use and regional gray matter volume in individuals at high risk of psychosis

Stone, James; Bhattacharyya, Sagnik; Barker, Gareth J; McGuire, Philip K; Bhattacharyya, Sagnik;
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  • Published: 01 Feb 2012
  • Country: United Kingdom
Abstract
Individuals with an at risk mental state (ARMS) are at greatly increased risk of developing a psychotic illness. Risk of transition to psychosis is associated with regionally reduced cortical gray matter volume. There has been considerable interest in the interaction between psychosis risk and substance use. In this study we investigate the relationship between alcohol, cannabis and nicotine use with gray matter volume in ARMS subjects and healthy volunteers. Twenty seven ARMS subjects and 27 healthy volunteers took part in the study. All subjects underwent volumetric MRI imaging. The relationship between regional gray matter volume and cannabis use, smoking, an...
Subjects
free text keywords: Pharmacology (medical), Biological Psychiatry, Pharmacology, Neurology, Psychiatry and Mental health, Clinical Neurology, Cannabis, biology.organism_classification, biology, Neuroplasticity, Psychiatry, medicine.medical_specialty, medicine, Gray (unit), Prefrontal cortex, Psychosis, medicine.disease, Temporal cortex, Psychology, Nicotine, medicine.drug, At risk mental state
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publication . Article . 2012

Substance use and regional gray matter volume in individuals at high risk of psychosis

Stone, James; Bhattacharyya, Sagnik; Barker, Gareth J; McGuire, Philip K; Bhattacharyya, Sagnik;