publication . Article . Other literature type . 2017

Evaluation of estrogen receptor alpha activation by glyphosate-based herbicide constituents

Mesnage, Robin; Phedonos, Alexia; Biserni, Martina; Arno, Matthew; Balu, Sucharitha; Corton, J. Christopher; Ugarte, Ricardo; Antoniou, Michael N.;
Open Access
  • Published: 01 Oct 2017 Journal: Food and Chemical Toxicology, volume 108, pages 30-42 (issn: 0278-6915, Copyright policy)
  • Publisher: Elsevier BV
  • Country: United Kingdom
Abstract
Abstract The safety, including the endocrine disruptive capability, of glyphosate-based herbicides (GBHs) is a matter of intense debate. We evaluated the estrogenic potential of glyphosate, commercial GBHs and polyethoxylated tallowamine adjuvants present as co-formulants in GBHs. Glyphosate (≥10,000 μg/L or 59 μM) promoted proliferation of estrogen-dependent MCF-7 human breast cancer cells. Glyphosate also increased the expression of an estrogen response element-luciferase reporter gene (ERE-luc) in T47D-KBluc cells, which was blocked by the estrogen antagonist ICI 182,780. Commercial GBH formulations or their adjuvants alone did not exhibit estrogenic effects ...
Subjects
Medical Subject Headings: hormones, hormone substitutes, and hormone antagonists
free text keywords: Endocrine disrupting effects, Pesticides, Glyphosate, Breast cancer, Toxicology, Food Science, General Medicine, IBMX, chemistry.chemical_compound, chemistry, Gene expression, Estrogen receptor alpha, Estrogen, medicine.drug_class, medicine, Reporter gene, Pharmacology, Receptor, Activator (genetics), Estrogen receptor
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publication . Article . Other literature type . 2017

Evaluation of estrogen receptor alpha activation by glyphosate-based herbicide constituents

Mesnage, Robin; Phedonos, Alexia; Biserni, Martina; Arno, Matthew; Balu, Sucharitha; Corton, J. Christopher; Ugarte, Ricardo; Antoniou, Michael N.;