publication . Article . Other literature type . 2016

Brain natriuretic peptide: Much more than a biomarker

Calzetta, Luigino; Orlandi, Augusto; Page, Clive; Rogliani, Paola; Rinaldi, Barbara; Rosano, Giuseppe; Cazzola, Mario; Matera, Maria Gabriella;
Open Access English
  • Published: 15 Oct 2016
Abstract
Brain natriuretic peptide (BNP) modulates several biological processes by activating the natriuretic peptide receptor A (NPR-A). Atria and ventricles secrete BNP. BNP increases natriuresis, diuresis and vasodilatation, thus resulting in a decreased cardiac workload. BNP and NT-proBNP, which is the biologically inactive N-terminal portion of its pro-hormone, are fast and sensitive biomarkers for diagnosing heart failure. The plasma concentrations of both BNP and NT-proBNP also correlate with left ventricular function in patients with acute exacerbation of COPD, even without history of heart failure. Several studies have been conducted in vitro and in vivo, both i...
Subjects
Medical Subject Headings: hormones, hormone substitutes, and hormone antagonistscardiovascular diseasescardiovascular system
free text keywords: BNP, NPR-A, asthma, COPD, human airway smooth muscle, Cardiology and Cardiovascular Medicine, Medicine, business.industry, business, Diuresis, Cardiology, medicine.medical_specialty, Heart failure, medicine.disease, Exacerbation, Internal medicine, Bronchial hyperresponsiveness, Biomarker (medicine), Brain natriuretic peptide, Natriuresis
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue