publication . Article . 1993

Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor

Masayuki Noguchi; Yoshiaki Nakamura; Sarah M. Russell; Steven F. Ziegler; Monica Tsang; Xiqing Cao; Warren J. Leonard;
Open Access
  • Published: 17 Dec 1993
Abstract
The interleukin-2 receptor gamma chain (IL-2R gamma) is a necessary component of functional IL-2 receptors. IL-2R gamma mutations result in X-linked severe combined immunodeficiency (XSCID) in humans, a disease characterized by the presence of few or no T cells. In contrast, SCID patients with IL-2 deficiency and IL-2-deficient mice have normal numbers of T cells, suggesting that IL-2R gamma is part of more than one cytokine receptor. By using chemical cross-linking, IL-2R gamma was shown to be physically associated with the IL-7 receptor. The presence of IL-2R gamma augmented both IL-7 binding affinity and the efficiency of internalization of IL-7. These findin...
Persistent Identifiers
Subjects
free text keywords: Multidisciplinary, Immunology, Interleukin 4, Common gamma chain, Receptor, Molecular biology, Cytokine receptor, Interleukin-21 receptor, Interleukin-7 receptor, Interleukin 2, medicine.drug, medicine, X-linked severe combined immunodeficiency, medicine.disease, Chemistry
Download fromView all 2 versions
Open Access
Science
Article
Provider: UnpayWall
Open Access
ZENODO
Article . 1993
Provider: ZENODO
Restricted
Science
Article . 1993
Provider: Crossref
Any information missing or wrong?Report an Issue