Mean expression of the X-chromosome is associated with neuronal density

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Swingland, James T.; Durrenberger, Pascal F.; Reynolds, Richard; Dexter, David T.; Pombo, Ana; DEPREZ, Manuel; Roncaroli, Federico; Turkheimer, Federico E.;
  • Journal: volume 6issn: 1662-4548, eissn: 1662-453X
  • Publisher copyright policies & self-archiving
  • Identifiers: pmc: PMC3495263, doi: 10.3389/fnins.2012.00161
  • Subject: Neuronal Concentration | Cardiovascular and Metabolic Diseases | : Neurology [Human health sciences] | : Neurologie [Sciences de la santé humaine] | Neuroscience | Wavelets | 570 Life Sciences | Original Research | Chromowave | Chromosome X | 610 Medical Sciences, Medicine | Dosage Compensation

Background: Neurodegenerative diseases are characterized by key features such as loss of neurons, astrocytosis, and microglial activation/proliferation. These changes cause differences in the density of cell types between control and disease subjects, confounding result... View more
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