publication . Article . Other literature type . 2015

A STING-dependent innate-sensing pathway mediates resistance to corneal HSV-1 infection via upregulation of the antiviral effector tetherin

Name: A STING-dependent innate-sensing pathway mediates resistance to corneal HSV-1 infection via upregulation of the antiviral effector tetherin
Keywords: Immunology, Immunology and Allergy, Article

Derek J. Royer; Daniel J. J. Carr;

Open Access

Published: 02 Dec 2015 Journal: Mucosal Immunology, volume 9, pages 1,065-1,075 (issn: 1933-0219, eissn: 1935-3456,

Publisher: Springer Science and Business Media LLC

Summary

Abstract

Type 1 interferons (IFNα/β) mediate immunologic host resistance to numerous viral infections including herpes simplex virus type 1 (HSV-1). The pathways responsible for maintenance of IFNα/β signaling during the innate immune response to acute HSV-1 infection in the cornea are incompletely understood. Using a murine ocular infection model, we hypothesized that the stimulator of IFN genes (STING) mediates host resistance to HSV-1 infection in the external ocular surface and preserves the structural integrity of this immune privileged mucosal site. Viral pathogenesis, tissue pathology, and host immune responses during ocular HSV-1 infection were evaluated and char...

doi: 10.1038/mi.2015.124

pmid: 26627457

pmc: PMC4889566

Subjects

Medical Subject Headings: eye diseasesviruses

free text keywords: Immunology, Immunology and Allergy, Article, Tetherin, Corneal epithelium, medicine.anatomical_structure, medicine, Immune system, Viral replication, Downregulation and upregulation, Sting, Biology, Innate immune system, Viral pathogenesis

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