publication . Other literature type . Article . 2015

Protocol For Evaluating Epigenetic Modulation Of The Renal Β-Adrenergic-Wnk4 Pathway In Salt-Sensitive Hypertension

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Open Access
  • Published: 24 Jan 2015
  • Publisher: Zenodo
Abstract
Authors: ShengYu Mu, Tatsuo Shimosawa & Toshiro Fujita ### Abstract In the current study, we found that β2 adrenergic receptor (β2AR) stimulation induced histone acetylation through HDAC8 inhibition, and then decreased transcription of the WNK4 gene by enhancing the binding of glucocorticoid receptor (GR) and negative-GR-responsive-element (nGRE) in WNK4 promoter region. Infusion of isoproterenol decreased WNK4 expression and activated the Na+-Cl- co-transporter in mice, which developed salt-induced hypertension. In rodent models of salt-sensitive hypertension and sympathetic over-activity, salt-loading suppressed renal WNK4 compared to controls, thus induci...
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Other literature type . 2015
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Article . 2015
Provider: ZENODO
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publication . Other literature type . Article . 2015

Protocol For Evaluating Epigenetic Modulation Of The Renal Β-Adrenergic-Wnk4 Pathway In Salt-Sensitive Hypertension

sprotocols;