publication . Article . Other literature type . 2018

Quality control in mass spectrometry-based proteomics

Francis Impens;
  • Published: 01 Sep 2018
  • Country: Belgium
Abstract
Mass spectrometry is a highly complex analytical technique and mass spectrometry-based proteomics experiments can be subject to a large variability, which forms an obstacle to obtaining accurate and reproducible results. Therefore, a comprehensive and systematic approach to quality control is an essential requirement to inspire confidence in the generated results. A typical mass spectrometry experiment consists of multiple different phases including the sample preparation, liquid chromatography, mass spectrometry, and bioinformatics stages. We review potential sources of variability that can impact the results of a mass spectrometry experiment occurring in all o...
Subjects
free text keywords: Chemistry, Biology, Computer. Automation, quality control, Sample preparation, Workflow, Shotgun proteomics, Proteomics, Bottom-up proteomics, Analytical technique, Chromatography, Sample complexity, Analytical chemistry, Mass spectrometry
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publication . Article . Other literature type . 2018

Quality control in mass spectrometry-based proteomics

Francis Impens;