publication . Article . 2011

Structures and functions of autotransporter proteins in microbial pathogens

Inga Benz; M. Alexander Schmidt;
Open Access
  • Published: 28 May 2011 Journal: International Journal of Medical Microbiology, volume 301, pages 461-468 (issn: 1438-4221, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Since their discovery more than 20 years ago the autotransporter protein superfamily has been growing continuously and currently represents the largest protein family in (pathogenic) Gram-negative bacteria. Autotransporter proteins (AT) adhere to a common structural principle and are composed of a C-terminal β-barrel-shaped 'translocator' domain and an N-terminal 'passenger' domain. The translocator is anchored in the outer membrane and is indispensable for the N-terminal passenger part to traverse the outer membrane. Most if not all AT harbor a chaperone segment that increases protein stability and may be located in the passenger or translocator domain. The pas...
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Subjects
free text keywords: Microbiology (medical), Microbiology, Infectious Diseases, General Medicine, Gram-negative bacteria, biology.organism_classification, biology, Protein family, Autotransporter domain, Membrane transport protein, biology.protein, Bacterial outer membrane, Biogenesis, Transport protein, Chaperone (protein), Biochemistry, Cell biology
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