publication . Article . 2011

sulfenic acids as reactive intermediates in xenobiotic metabolism

Mansuy, Daniel; Dansette, Patrick M.;
Open Access
  • Published: 01 Mar 2011 Journal: Archives of Biochemistry and Biophysics, volume 507, pages 174-185 (issn: 0003-9861, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Abstract Sulfenic acid reactive intermediates are formed during the oxidation of cysteine residues of proteins and play key roles in enzyme catalysis, redox homeostasis and regulation of cell signalling. However few data are presently available on the formation and fate of sulfenic acids as reactive intermediates during the metabolism of xenobiotics. This article is a review of the xenobiotic metabolism situations in which the intermediate formation of a sulfenic acid has been reported. Formation of these intermediates has been either proposed on the basis of the isolation of products possibly deriving from sulfenic acids or shown after trapping of the sulfenic ...
Subjects
free text keywords: Biophysics, Biochemistry, Molecular Biology, Chemistry, Cysteine, Sulfenic acid, chemistry.chemical_compound, Reactive intermediate, Enzyme catalysis, Drug metabolism, Xenobiotic, Metabolism, Cytochrome P450, biology.protein, biology
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publication . Article . 2011

sulfenic acids as reactive intermediates in xenobiotic metabolism

Mansuy, Daniel; Dansette, Patrick M.;