publication . Article . 2021

Targeting Alzheimer's disease with multimodal polypeptide-based nanoconjugates

Duro-Castano, A.; Borrás, C.; Herranz-Pérez, V.; Blanco-Gandía, M. C.; Conejos-Sánchez, I.; Armiñán, A.; Mas-Bargues, C.; Inglés, M.; Miñarro, J.; Rodríguez-Arias, M.; ...
Open Access
  • Published: 26 Mar 2021
  • Country: Spain
Abstract
Alzheimer’s disease (AD), the most prevalent form of dementia, remains incurable mainly due to our failings in the search for effective pharmacological strategies. Here, we describe the development of targeted multimodal polypeptide-based nanoconjugates as potential AD treatments. Treatment with polypeptide nanoconjugates bearing propargylamine moieties and bisdemethoxycurcumin or genistein afforded neuroprotection and displayed neurotrophic effects, as evidenced by an increase in dendritic density of pyramidal neurons in organotypic hippocampal culture. The additional conjugation of the Angiopep-2 targeting moiety enhanced nanoconjugate passage through the bloo...
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free text keywords: Research Article, Research Articles, SciAdv r-articles, Applied Sciences and Engineering, Life Sciences, Alzheimer’s disease (AD), AD treatment
Funded by
EC| MyNano
Project
MyNano
Towards the design of Personalised Polymer-based Combination Nanomedicines for Advanced Stage Breast Cancer Patients
  • Funder: European Commission (EC)
  • Project Code: 648831
  • Funding stream: H2020 | ERC | ERC-COG
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