Fanconi anemia protein complex is a novel target of the IKK signalsome

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Otsuki, Tetsuya; Young, David B.; Sasaki, Dennis T.; Pando, Matthew P.; Li, Jianwu; Manning, Anthony; Hoekstra, Merl; Hoatlin, Maureen E.; Mercurio, Frank; Liu, Johnson M.;
  • Related identifiers: doi: 10.1002/jcb.10270
  • Subject:
    mesheuropmc: hemic and lymphatic diseases | congenital, hereditary, and neonatal diseases and abnormalities | nutritional and metabolic diseases

Fanconi anemia (FA), a genetic disorder predisposing to aplastic anemia and cancer, is characterized by hypersensitivity to DNA‐damaging agents and oxidative stress. Five of the cloned FA proteins (FANCA, FANCC, FANCE, FANCF, FANCG) appear to be involved in a common fun... View more
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