publication . Article . 2002

Modulation of ATP-Dependent Chromatin-Remodeling Complexes by Inositol Polyphosphates

Ryan T. Ranallo; Carl Wu; Xuetong Shen; Hua Xiao; Wei Hua Wu;
Open Access
  • Published: 14 Nov 2002 Journal: Science, volume 299, pages 112-114 (issn: 0036-8075, eissn: 1095-9203, Copyright policy)
  • Publisher: American Association for the Advancement of Science (AAAS)
Abstract
Eukaryotes use adenosine triphosphate (ATP)–dependent chromatin-remodeling complexes to regulate gene expression. Here, we show that inositol polyphosphates can modulate the activities of several chromatin-remodeling complexes in vitro. Inositol hexakisphosphate (IP6) inhibits nucleosome mobilization by NURF, ISW2, and INO80 complexes. In contrast, nucleosome mobilization by the yeast SWI/SNF complex is stimulated by inositol tetrakisphosphate (IP4) and inositol pentakisphosphate (IP5). We demonstrate that mutations in genes encoding inositol polyphosphate kinases that produce IP4, IP5, and IP6 impair transcription in vivo. These results provide a link between i...
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doi: 10.1126/science.1078068
Subjects
free text keywords: Multidisciplinary, ATP-dependent chromatin remodeling, Chromatin remodeling, Inositol pentakisphosphate, chemistry.chemical_compound, chemistry, Biology, Inositol, Chromatin, Biochemistry, Nucleosome mobilization, Inositol phosphate, chemistry.chemical_classification, Inositol trisphosphate receptor
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