publication . Other literature type . Article . 2017

Analytical Method Development And Validation For The Simultaneous Estimation Of Sofosbuvir And Daclatasvir Drug Product By Rp-Hplc Method

Benzil Dudekula1*, Dr.C.Ramachandraiah2;
Open Access
  • Published: 30 Aug 2017
  • Publisher: Zenodo
Abstract
Analytical method was developed for the estimation of Sofosbuvir and Daclatasvir drug substance by liquid chromatography. The chromatographic separation was achieved on C18 column (XTerra RP18 150*4.6, 5um) at ambient temperature .The separation achieved employing a mobile phase consists of 0.1%v/v Trifluoro acetic acid in water: Acetonitrile (60:40). The flow rate was 1.0 ml/ minute and ultra violet detector at 275nm. The average retention time for Sofosbuvir and Daclatasvir found to be 2.09 and 3.50 min. The proposed method was validated for selectivity, precision, linearity and accuracy. All validation parameters were within the acceptable range. The assay me...
Subjects
free text keywords: Sofosbuvir And Daclatasvir, Isocratic, HPLC, C18, Trifluoro Acetic Acid, Methanol, Acetonitrile And Validation.
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Zenodo
Other literature type . 2017
Provider: Datacite
Zenodo
Other literature type . 2017
Provider: Datacite
Zenodo
Other literature type . 2017
Provider: Datacite
ZENODO
Article . 2017
Provider: ZENODO
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publication . Other literature type . Article . 2017

Analytical Method Development And Validation For The Simultaneous Estimation Of Sofosbuvir And Daclatasvir Drug Product By Rp-Hplc Method

Benzil Dudekula1*, Dr.C.Ramachandraiah2;