publication . Other literature type . Article . 2015

The Use Of Optical Magnetic Twisting Cytometry And Flourescence Resonance Energy Transfer To Quantify Force-Induced Protein Dissociation In The Nucleus Of A Living Cell

Open Access
  • Published: 10 Jan 2015
  • Publisher: Zenodo
Authors: Yeh-Chuin Poh & Ning Wang ### Abstract Mechanical forces are known to play a significant role in biological processes. These forces can be transmitted to the cell through the cytoskeletal filament network, inducing different biochemical responses within the cytoplasm. Although there have been ample reports showing that cytoplasmic enzymes can be directly activated by a local stress on the cell surface via integrins, there has been no evidence that mechanical forces can directly alter nuclear functions without intermediate biochemical cascades. Recently, we showed evidence that forces on the cell membrane can be transmitted directly into the nucleus,...
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Other literature type . 2015
Provider: Datacite
Article . 2015
Provider: ZENODO
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