publication . Other literature type . Article . 2015

The Use Of Optical Magnetic Twisting Cytometry And Flourescence Resonance Energy Transfer To Quantify Force-Induced Protein Dissociation In The Nucleus Of A Living Cell

Name: The Use Of Optical Magnetic Twisting Cytometry And Flourescence Resonance Energy Transfer To Quantify Force-Induced Protein Dissociation In The Nucleus Of A Living Cell
Creator: sprotocols

sprotocols;

Open Access

Published: 10 Jan 2015

Publisher: Zenodo

Summary

Abstract

Authors: Yeh-Chuin Poh & Ning Wang ### Abstract Mechanical forces are known to play a significant role in biological processes. These forces can be transmitted to the cell through the cytoskeletal filament network, inducing different biochemical responses within the cytoplasm. Although there have been ample reports showing that cytoplasmic enzymes can be directly activated by a local stress on the cell surface via integrins, there has been no evidence that mechanical forces can directly alter nuclear functions without intermediate biochemical cascades. Recently, we showed evidence that forces on the cell membrane can be transmitted directly into the nucleus,...

doi: 10.5281/zenodo.13873

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Zenodo

Other literature type . 2015

Provider: Datacite

ZENODO

Article . 2015

Provider: ZENODO

Zenodo

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