publication . Article . 2015

Estrogen accelerates the resolution of inflammation in macrophagic cells

Alessandro Villa; Nicoletta Rizzi; Elisabetta Vegeto; Paolo Ciana; Adriana Maggi;
Open Access English
  • Published: 19 Oct 2015 Journal: Scientific Reports, volume 5 (eissn: 2045-2322, Copyright policy)
  • Publisher: Nature Publishing Group
  • Country: Italy
Abstract
Although 17β-estradiol (E2) anti-inflammatory activity has been well described, very little is known about the effects of this hormone on the resolution phase of the inflammatory process. Here, we identified a previously unreported ERα-mediated effect of E2 on the inflammatory machinery. The study showed that the activation of the intracellular estrogen receptor shortens the LPS-induced pro-inflammatory phase and, by influencing the intrinsic and extrinsic programs, triggers the resolution of inflammation in RAW 264.7 cells. Through the regulation of the SOCS3 and STAT3 signaling pathways, E2 facilitates the progression of the inflammatory process toward the IL1...
Subjects
free text keywords: Article, Multidisciplinary, Settore BIO/14 - Farmacologia, Inflammation, medicine.symptom, medicine, Interleukin 10, Interleukin 4, Immunology, Cancer research, Estrogen receptor alpha, Estrogen, medicine.drug_class, Estrogen receptor, Macrophage inflammatory protein, Biology, SOCS3
Funded by
EC| WAYS
Project
WAYS
Role of Liver Estrogen Receptor in female Energy Metabolism, Reproduction and Aging: What About Your Liver Sexual Functions?
  • Funder: European Commission (EC)
  • Project Code: 322977
  • Funding stream: FP7 | SP2 | ERC
,
EC| INMIND
Project
INMIND
Imaging of Neuroinflammation in Neurodegenerative Diseases
  • Funder: European Commission (EC)
  • Project Code: 278850
  • Funding stream: FP7 | SP1 | HEALTH
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