publication . Article . 2018

Susceptibilities of clinical Clostridium difficile isolates to antimicrobials: a systematic review and meta-analysis of studies since 1970

Andrew E. Simor; Nick Daneman; Matthew H. Samore; Philippe Vanhems; N. Khanafer; Tom Greene; Kevin A. Brown;
Open Access
  • Published: 01 Feb 2018
  • Country: France
Abstract
Abstract Objectives Although exposure to antibiotics can cause Clostridium difficile infection, certain antibiotics are used to treat C. difficile . Measurements of antimicrobial C. difficile activity could help to identify antibiotic risk and emergent resistance. Here, we describe publication patterns relating to C. difficile susceptibilities and estimate minimum inhibitory concentrations (MIC) for antibiotic classes in the published literature between January 1970 and June 2014. Methods We queried PUBMED and EMBASE for studies reporting antibiotic C. difficile MIC in English or French. We used mixed-effects models to obtain pooled estimates of antibiotic class...
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doi: 10.1016/j.cmi.2017.07.012
Subjects
free text keywords: Microbiology (medical), Infectious Diseases, General Medicine, Humans, Strain, Pseudomembranous, Anti-Bacterial Agents, Antibiotic, Drug Resistance, Bacterial, Enterocolitis, Susceptibility, [SDV.IMM]Life Sciences [q-bio]/Immunology, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Antibiotics, medicine.drug_class, medicine, business.industry, business, Antimicrobial stewardship, Cephalosporin, Microbiology, Rifamycins, Minimum inhibitory concentration, Meta-analysis, Clostridium difficile, Antimicrobial
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