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A universal biomolecular integral feedback controller for robust perfect adaptation

Aoki, Stephanie K.; Lillacci, Gabriele; Gupta, Ankit; Baumschlager, Armin; Schweingruber, David; Khammash, Mustafa;
Open Access
Abstract Homeostasis is a recurring theme in biology that ensures that regulated variables robustly—and in some systems, completely—adapt to environmental perturbations. This robust perfect adaptation feature is achieved in natural circuits by using integral control, a negative feedback strategy that performs mathematical integration to achieve structurally robust regulation. Despite its benefits, the synthetic realization of integral feedback in living cells has remained elusive owing to the complexity of the required biological computations. Here we prove mathematically that there is a single fundamental biomolecular controller topology that reali...
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