publication . Article . Other literature type . 2002

Repair of 8-oxoG is slower in endogenous nuclear genes than in mitochondrial DNA and is without strand bias

Tina Thorslund; Morten Sunesen; Vilhelm A. Bohr; Tinna Stevnsner;
Open Access
  • Published: 01 Apr 2002
Abstract
DNA is vulnerable to the attack of certain oxygen radicals and one of the major DNA lesions formed is 7,8-dihydro-8-oxoguanine (8-oxoG), a highly mutagenic lesion that can mispair with adenine. The repair of 8-oxoG was studied by measuring the gene specific removal of 8-oxoG after treatment of Chinese hamster ovary (CHO) fibroblasts with the photosensitizer Ro19-8022. This compound introduces 8-oxoG lesions, which can then be detected with the Escherichia coli formamidopyrimidine DNA glycosylase (FPG). In this report we present gene specific repair analysis of endogenous genes situated in different important cellular regions and also the first analysis of strand...
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Medical Subject Headings: heterocyclic compounds
free text keywords: Nucleotide excision repair, Homology directed repair, Biology, DNA damage, Replication protein A, Formamidopyrimidine DNA glycosylase, DNA repair protein XRCC4, DNA mismatch repair, Molecular biology, DNA repair
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