publication . Article . 2006

Viral RNA in the bloodstream suggests viremia occurs in clinically ill rabies-infected mice

Donald L. Lodmell; Derek E. Dimcheff; Larry C. Ewalt;
Open Access
  • Published: 01 Mar 2006 Journal: Virus Research, volume 116, pages 114-118 (issn: 0168-1702, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Abstract Data regarding the occurrence of a viremia during rabies virus infections are contradictory. Here, we attempted to clarify the dissimilar results using a qualitative TaqMan PCR assay to detect viral RNA in blood of mice that had been injected intramuscularly with rabies virus. Viral RNA was detected at two different intervals. Initially, RNA was present in blood of 30/32 (94%) mice, from 1 h to 2 days after injection of virus. The RNA in the blood at this time most likely resulted from trauma to blood vessels at the injection site and leakage of the inoculated virus into the circulation. Thereafter, from 3 to 30 days, viral RNA was undetectable in the b...
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Medical Subject Headings: viruses
free text keywords: Cancer Research, Virology, Infectious Diseases, Rabies, medicine.disease, medicine, Viral replication, Virus, Biology, Viral load, Rabies virus, medicine.disease_cause, Virus-neutralizing Antibody, Immunology, RNA, Viremia
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