publication . Other literature type . Article . 2005

TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein

Alan Sher; Matthew S. Hayden; Dekai Zhang; Felix Yarovinsky; Gerard Bannenberg; Richard A. Flavell; Fayyaz S. Sutterwala; John F. Andersen; Charles N. Serhan; Sankar Ghosh; ...
Open Access
  • Published: 10 Jun 2005
  • Publisher: American Association for the Advancement of Science (AAAS)
Abstract
Mammalian Toll-like receptors (TLRs) play an important role in the innate recognition of pathogens by dendritic cells (DCs). Although TLRs are clearly involved in the detection of bacteria and viruses, relatively little is known about their function in the innate response to eukaryotic microorganisms. Here we identify a profilin-like molecule from the protozoan parasite Toxoplasma gondii that generates a potent interleukin-12 (IL-12) response in murine DCs that is dependent on myeloid differentiation factor 88. T. gondii profilin activates DCs through TLR11 and is the first chemically defined ligand for this TLR. Moreover, TLR11 is required in vivo for parasite-...
Subjects
Medical Subject Headings: parasitic diseases
free text keywords: Multidisciplinary, Innate immune system, Interleukin 12, Receptor, Virology, Toll-like receptor, Toxoplasma gondii, biology.organism_classification, biology, Dendritic cell, Cell biology, Myeloid Differentiation Factor 88, Profilin, biology.protein
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