publication . Article . 1990

Molecular targets for AIDS therapy

Hiroaki Mitsuya; Robert Yarchoan; Samuel Broder;
Open Access
  • Published: 28 Sep 1990
Abstract
The development of antiretroviral therapy against acquired immunodeficiency syndrome (AIDS) has been an intense research effort since the discovery of the causative agent, human immunodeficiency virus (HIV). A large array of drugs and biologic substances can inhibit HIV replication in vitro. Nucleoside analogs--particularly those belonging to the dideoxynucleoside family--can inhibit reverse transcriptase after anabolic phosphorylation. 3'-Azido-2',3'-dideoxythymidine (AZT) was the first such drug tested in individuals with AIDS, and considerable knowledge of structure-activity relations has emerged for this class of drugs. However, virtually every step in the r...
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free text keywords: Multidisciplinary, Virology, Drug, media_common.quotation_subject, media_common, Viral replication, Acquired immunodeficiency syndrome (AIDS), medicine.disease, medicine, Immunology, Immunotherapy, medicine.medical_treatment, Immunopathology, Reverse transcriptase, Dideoxynucleosides, business.industry, business, Viral disease
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