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Optimal control of an artificial microbial differentiation system for protein bioproduction

Weill, Élise; Andréani, Virgile; Aditya, Chetan; Martinon, Pierre; Ruess, Jakob; Batt, Grégory; Bonnans, Frédéric;
Open Access
<p>Abstract</p> <p>The production of recombinant proteins is a problem of significant interest in bioengineering. Because of the existing trade-off between cellular growth and protein production, these two processes are separated in time in most commonly-employed strategies: a growth phase is followed by a production phase. Here, we investigate the potential of an alternative strategy using artificial cell specialization and differentiation systems in which cells either grow (&ldquo;growers&rdquo;) or produce proteins (&ldquo;producers&rdquo;) and growers can irreversibly &ldquo;differentiate&rdquo; into producers. Inspired by an existing two-population system ...
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Funded by
Control Engineering of Biological Systems for Reliable Synthetic Biology Applications
  • Funder: European Commission (EC)
  • Project Code: 766840
  • Funding stream: H2020
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