Improving the phenotype predictions of a yeast genome‐scale metabolic model by incorporating enzymatic constraints

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Sánchez, Benjamín J; Zhang, Cheng; Nilsson, Avlant; Lahtvee, Petri‐Jaan; Kerkhoven, Eduard J; Nielsen, Jens;
  • Publisher: John Wiley and Sons Inc.
  • Journal: Molecular Systems Biology,volume 13,issue 8,page935 (issn: 1744-4292 1744-4292, eissn: 1744-4292)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC5572397, doi: 10.15252/msb.20167411
  • Subject: flux balance analysis | proteomics | Oceanography, Hydrology and Water Resources | Methods & Resources | molecular crowding | Genome-Scale & Integrative Biology | Metabolism | Articles | enzyme kinetics | Oceanografi, hydrologi och vattenresurser | Article | Saccharomyces cerevisiae

Genome-scale metabolic models (GEMs) are widely used to calculate metabolic phenotypes. They rely on defining a set of constraints, the most common of which is that the production of metabolites and/or growth are limited by the carbon source uptake rate. However, enzyme... View more
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