publication . Other literature type . Article . 2018

Huntington'S Disease: Understanding The Pathophysiology Through The Huntingtin Gene

Md. Nasrullah;
Open Access English
  • Published: 29 Jan 2018
  • Publisher: Zenodo
Abstract
Huntington's Disease (HD) is a progressive neurodegenerative disorder. It is an autosomal dominant disorder that is categorized by motor dysfunctions, behavioral and cognitive deficits. Reason for this disease is expansion of the polyglutamine (due to the more CAG repeat) in the amino-terminal region of the exon 1 of the Huntingtin gene (HTT). Furthermore, the mutant HTT gene is occupied in the HD associated changes of neurotransmission for enabling the neurodegeneration. Even though the the important pathophysiology of the HD happens in the caudate and putamen, rest regions of the brain are similarly influenced and also show a significant characteristic in the ...
Subjects
Medical Subject Headings: mental disorderscongenital, hereditary, and neonatal diseases and abnormalitiesnervous system diseasesnervous system
free text keywords: huntington's disease; Neurodegenerative Disorders; Pathophysiology; Huntingtin gene
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Zenodo
Other literature type . 2018
Provider: Datacite
ZENODO
Article . 2018
Provider: ZENODO
Zenodo
Other literature type . 2018
Provider: Datacite
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publication . Other literature type . Article . 2018

Huntington'S Disease: Understanding The Pathophysiology Through The Huntingtin Gene

Md. Nasrullah;