publication . Article . 1994

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

I-Tsuen Chen; Qimin Zhan; Insoo Bae; Tona M. Gilmer; Patrick M. O'Connor; Michael B. Kastan; Martin L. Smith; C Y Chen; Albert J. Fornace;
Open Access
  • Published: 25 Nov 1994 Journal: Science, volume 266, pages 1,376-1,380 (issn: 0036-8075, eissn: 1095-9203, Copyright policy)
  • Publisher: American Association for the Advancement of Science (AAAS)
Abstract
GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21WAF1/CIP1, whose product binds to cyclin-dependent kinases (Cdk's) and proliferating cell nuclear antigen (PCNA), GADD45 has been associated with growth suppression. Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S phase. These results establish GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.
Subjects
free text keywords: Multidisciplinary, DNA damage, Control of chromosome duplication, Proliferating cell nuclear antigen, biology.protein, biology, DNA polymerase delta, Replication protein A, DNA repair, G2-M DNA damage checkpoint, Eukaryotic DNA replication, Molecular biology
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