publication . Article . 1994

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

M. Smith; I. Chen; Q Zhan; I Bae; C. Chen; T. Gilmer; M. Kastan; P. O'Connor; A. Fornace;
Open Access
  • Published: 25 Nov 1994
Abstract
GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21WAF1/CIP1, whose product binds to cyclin-dependent kinases (Cdk9s) and proliferating cell nuclear antigen (PCNA), GADD45 has been associated with growth suppression. Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S phase. These results establish GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.
Subjects
free text keywords: Multidisciplinary, G2-M DNA damage checkpoint, Proliferating cell nuclear antigen, biology.protein, biology, Control of chromosome duplication, Molecular biology, DNA damage, DNA repair, DNA polymerase delta, Replication protein A, Eukaryotic DNA replication
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publication . Article . 1994

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

M. Smith; I. Chen; Q Zhan; I Bae; C. Chen; T. Gilmer; M. Kastan; P. O'Connor; A. Fornace;