publication . Article . Other literature type . 1996

Neonatal Tolerance Revisited: Turning on Newborn T Cells with Dendritic Cells

John Paul Ridge; Ephraim J. Fuchs; Polly Matzinger;
Open Access
  • Published: 22 Mar 1996
Abstract
For some time it has been thought that antigenic challenge in neonatal life is a tolerogenic rather than immunogenic event. Reexamination of the classic neonatal tolerance experiments of Billingham, Brent, and Medawar showed that tolerance is not an intrinsic property of the newborn immune system, but that the nature of the antigen-presenting cell determines whether the outcome is neonatal tolerance or immunization.
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Medical Subject Headings: chemical and pharmacologic phenomena
free text keywords: Multidisciplinary, Immune system, Recien nacido, T lymphocyte, Immunology, Antigen, Biology, Antigen presentation, Immune tolerance, Cell, medicine.anatomical_structure, medicine, Neonatal life
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