publication . Article . 1996

Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively

O.W. McBride; H. Yi; D.G. Guerini; Mary G. Wang; C.B. Klee;
Open Access
  • Published: 01 Jan 1996 Journal: Cytogenetic and Genome Research, volume 72, pages 236-241 (issn: 1424-8581, eissn: 1424-859X, Copyright policy)
  • Publisher: S. Karger AG
Abstract
Calcineurin (also called protein phosphatase-2B) is a calmodulin-regulated protein phosphatase which plays an important role in signal transduction. The enzyme is a heterodimer of a 58–59 kDa calmodulin-binding catalytic subunit (calcineurin A) and a small (i.e. 19 kDa) Ca2+-binding regulatory subunit (calcineurin B). The highly conserved calcineurin B is encoded by a single gene in all tissues except testes, whereas there are three isoforms of calcineurin A (α, β and γ) encoded by genes on three different chromosomes. This enzyme can play a critical role in transcriptional regulation and growth control in T lymphocytes by a mechanism believed to involve dephosp...
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free text keywords: Genetics(clinical), Genetics, Molecular Biology, Enzyme, chemistry.chemical_classification, chemistry, Calmodulin, biology.protein, biology, Gene, Phosphoric monoester hydrolases, Binding protein, Calcineurin, Phosphatase, Signal transduction
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