publication . Other literature type . Article . 2015

Acute neuroinflammation in a clinically relevant focal cortical ischemic stroke model in rat: longitudinal positron emission tomography and immunofluorescent tracking

Christer Halldin; Christer Halldin; Jan Mulder; Miklós Tóth; Jenny Häggkvist; Philip Little; Philip Little; Balázs Gulyás; Balázs Gulyás; Balázs Gulyás; ...
Open Access
  • Published: 20 Jan 2015
  • Publisher: Springer Science and Business Media LLC
Abstract
Adequate estimation of neuroinflammatory processes following ischemic stroke is essential for better understanding of disease mechanisms, and for the development of treatment strategies. With the TSPO (18 kDa translocator protein) positron emission tomography (PET) radioligand [11C]PBR28, we monitored longitudinally the inflammatory response post-transient cerebral ischemia in rats, using a recently developed rat stroke model that produces isolated focal cortical infarcts with clinical relevance in size and pathophysiology. Six Sprague-Dawley rats were subjected to 90 min transient endovascular occlusion of the M2 segment of the middle cerebral artery (M2CAO). A...
Subjects
free text keywords: Anatomy, General Neuroscience, Histology, Positron emission tomography (PET), [11C]PBR28, M2CAO, Rat, Ischemia, medicine.disease, medicine, Positron emission tomography, medicine.diagnostic_test, Radioligand, Translocator protein, biology.protein, biology, Pathology, medicine.medical_specialty, Middle cerebral artery, medicine.artery, Glial fibrillary acidic protein, Neuroinflammation, Stroke, business.industry, business
Funded by
EC| INMIND
Project
INMIND
Imaging of Neuroinflammation in Neurodegenerative Diseases
  • Funder: European Commission (EC)
  • Project Code: 278850
  • Funding stream: FP7 | SP1 | HEALTH
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