publication . Article . Other literature type . 2019

Coupling of DNA Circuit and Templated Reactions for Quadratic Amplification and Release of Functional Molecules

Ki Tae Kim; Dalu Chang; Nicolas Winssinger; Simona Angerani;
Open Access English
  • Published: 16 Jul 2019
  • Country: Switzerland
Abstract
DNA-based circuitry empowers logic gated operations and amplifications but is restricted to nucleic acid output. Templated reactions enable the translation of nucleic acid cues into diverse small-molecule outputs but are more limited in their amplification. Herein, we demonstrate the coupling of a DNA circuit to templated reactions in order to achieve high levels of amplification in the output of small molecules, in response to nucleic acid input. We demonstrate that the coupling of the DNA circuit to templated reactions allows for the detection of the fM concentration of analyte and can respond with the release of a cytotoxic drug.
Subjects
free text keywords: Colloid and Surface Chemistry, Biochemistry, General Chemistry, Catalysis, ddc:540, Chemistry, Coupling, Nucleic acid, Combinatorial chemistry, Functional importance, Analyte, A-DNA, Cytotoxic drug, Small molecule, DNA, chemistry.chemical_compound
Related Organizations
Funded by
SNSF| Probes for chemical biology: from synthesis to biosupramolecular systems
Project
  • Funder: Swiss National Science Foundation (SNSF)
  • Project Code: 200020_169141
  • Funding stream: Project funding | Project funding (Div. I-III)
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Zenodo
Other literature type . 2019
Provider: Datacite
ZENODO
Article . 2019
Provider: ZENODO
Zenodo
Other literature type . 2019
Provider: Datacite
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