publication . Article . Other literature type . 2005

Determination of modafinil in plasma and urine by reversed phase high-performance liquid-chromatography

Harvey A. Schwertner; Suk Bin Kong;
Open Access
  • Published: 01 Mar 2005 Journal: Journal of Pharmaceutical and Biomedical Analysis, volume 37, pages 475-479 (issn: 0731-7085, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Modafinil (Provigil) is a new wake-promoting drug that is being used for the management of excessive sleepiness in patients with narcolepsy. It has pharmacological properties similar to that of amphetamine, but without some of the side effects associated with amphetamine-like stimulants. Since modafinil has the potential to be abused, accurate drug-screening methods are needed for its analysis. In this study, we developed a high-performance liquid-chromatographic procedure (HPLC) for the quantitative analysis of modafinil in plasma and urine. (Phenylthio)acetic acid was used as an internal standard for the analysis of both plasma and urine. Modafinil was extract...
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free text keywords: Chromatography, Pharmacology, Therapeutic drug monitoring, medicine.diagnostic_test, medicine, High-performance liquid chromatography, Modafinil, medicine.drug, Chemistry, Urine, Reversed-phase chromatography, Quantitative analysis (chemistry), Pharmacokinetics, Ethyl acetate, chemistry.chemical_compound
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