publication . Article . Other literature type . 2015

Covalently-crosslinked mucin biopolymer hydrogels for sustained drug delivery.

Connor V. Duffy; Laurent David; Thomas Crouzier;
Open Access English
  • Published: 01 Jul 2015
  • Publisher: HAL CCSD
  • Country: France
Abstract
International audience; The sustained delivery of both hydrophobic and hydrophilic drugs from hydrogels has remained a challenge requiring the design and scalable production of complex multifunctional synthetic polymers. Here, we demonstrate that mucin glycoproteins, the gel-forming constituents of native mucus, are suitable for assembly into robust hydrogels capable of facilitating the sustained release of hydrophobic and hydrophilic drugs. Covalently-crosslinked mucin hydrogels were generated via exposure of methacrylated mucin to ultraviolet light in the presence of a free radical photoinitiator. The hydrogels exhibited an elastic modulus similar to that of s...
Subjects
free text keywords: mucins, hydrogel, mucus, polymyxin B, paclitaxel, sustained release, Mucin hydrogel, Amphiphile, Crosslinking, Drug delivery, Methacrylation, [CHIM.POLY]Chemical Sciences/Polymers, [CHIM.MATE]Chemical Sciences/Material chemistry, medicine.drug, medicine, Mucin, Biochemistry, Ultraviolet light, Biopolymer, engineering.material, engineering, Self-healing hydrogels, Pronase, Materials science
Funded by
EC| BIOMUC
Project
BIOMUC
Mucin binding to bioactive molecules: physiological role and new biomaterials
  • Funder: European Commission (EC)
  • Project Code: 300011
  • Funding stream: FP7 | SP3 | PEOPLE
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publication . Article . Other literature type . 2015

Covalently-crosslinked mucin biopolymer hydrogels for sustained drug delivery.

Connor V. Duffy; Laurent David; Thomas Crouzier;