publication . Article . 2012

Griebel G, Holsboer F. Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning? Nat Rev Drug Discov 11: 462-478

Guy Griebel; Florian Holsboer;
Open Access
  • Published: 18 May 2012
The search for novel drugs for treating psychiatric disorders is driven by the growing medical need to improve on the effectiveness and side-effect profile of currently available therapies. Given the wealth of preclinical data supporting the role of neuropeptides in modulating behaviour, pharmaceutical companies have been attempting to target neuropeptide receptors for over two decades. However, clinical studies with synthetic neuropeptide ligands have been unable to confirm the promise predicted by studies in animal models. Here, we analyse preclinical and clinical results for neuropeptide receptor ligands that have been studied in clinical trials for psychiatr...
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free text keywords: Pharmacology, Drug Discovery, General Medicine, Receptor, Preclinical data, Neurotensin, chemistry.chemical_compound, chemistry, Psychiatry, medicine.medical_specialty, medicine, Clinical trial, Neuropeptide, business.industry, business, Neuropeptide receptor
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