publication . Other literature type . Article . 2017

Estimation Of Hydrochlorothiazide In Bulk And Tablet Dosage Forms By Area Under Curve Spectrophotometric Method

Mangal B Gahandule*, Shanker M Dhobale1;
Open Access
  • Published: 31 Jan 2017
  • Publisher: Zenodo
Abstract
A simple, accurate and precise area under curve method was developed for spectrophotometric estimation of hydrochlorothiazide in pure and tablet dosage forms. “The area under two points on the mixture spectra is directly proportional to the concentration of the component of interest” is the AUC curve. The area selected for estimation of hydrochlorothiazide was between 260 to 280 nm. The method represented regression coefficient (R2 = 0.999) at concentration rang 5-25 μg/ml. Estimation of the drugs was found up to 100 % representing the accuracy of the method. The recovery of the hydrochlorothiazide was found up to 100 %. Validation of the proposed method was car...
Subjects
free text keywords: Hydrochlorothiazide, Area Under Curve, ICH Q2 (R1) Guidelines, Validation.
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Zenodo
Other literature type . 2017
Provider: Datacite
Zenodo
Other literature type . 2017
Provider: Datacite
Zenodo
Other literature type . 2017
Provider: Datacite
Zenodo
Other literature type . 2017
Provider: Datacite
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