publication . Article . Other literature type . 2001

Structure and Function of Sulfotransferases

Lars C. Pedersen; Lee G. Pedersen; Lee G. Pedersen; Masahiko Negishi; Evgeniy V. Petrotchenko; Sergei Shevtsov; Yoshimitsu Kakuta; Anna Gorokhov;
Open Access
  • Published: 01 Jun 2001
Abstract
Sulfotransferases (STs) catalyze the transfer reaction of the sulfate group from the ubiquitous donor 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to an acceptor group of numerous substrates. This reaction, often referred to as sulfuryl transfer, sulfation, or sulfonation, is widely observed from bacteria to humans and plays a key role in various biological processes such as cell communication, growth and development, and defense. The cytosolic STs sulfate small molecules such as steroids, bioamines, and therapeutic drugs, while the Golgi-membrane counterparts sulfate large molecules including glucosaminylglycans and proteins. We have now solved the X-ray crysta...
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free text keywords: Biophysics, Biochemistry, Molecular Biology, Sulfuryl, chemistry.chemical_compound, chemistry, Small molecule, Substrate (chemistry), Stereochemistry, Membrane, Sulfation, Globular protein, chemistry.chemical_classification, Enzyme, Cytosol
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