publication . Article . Part of book or chapter of book . Other literature type . 2001

Structure and function of sulfotransferases.

Lars Pedersen; Masahiko Negishi;
Open Access
  • Published: 01 Jun 2001 Journal: Archives of Biochemistry and Biophysics, volume 390, pages 149-157 (issn: 0003-9861, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Abstract Sulfotransferases (STs) catalyze the transfer reaction of the sulfate group from the ubiquitous donor 3′-phosphoadenosine 5′-phosphosulfate (PAPS) to an acceptor group of numerous substrates. This reaction, often referred to as sulfuryl transfer, sulfation, or sulfonation, is widely observed from bacteria to humans and plays a key role in various biological processes such as cell communication, growth and development, and defense. The cytosolic STs sulfate small molecules such as steroids, bioamines, and therapeutic drugs, while the Golgi-membrane counterparts sulfate large molecules including glucosaminylglycans and proteins. We have now solved the X-r...
Subjects
free text keywords: Biophysics, Biochemistry, Molecular Biology
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