publication . Article . 2010

linkage between sexual orientation and chromosome xq28 in males but not in females

Hu Stella; Pattatucci Angela M. L.; Patterson Chavis; Li Lin; Fulker David W.; Cherny Stacey S.; Kruglyak Leonid; Hamer Dean H.;
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  • Published: 18 Nov 2010 Journal: Nature Genetics, volume 11, pages 248-256 (issn: 1061-4036, eissn: 1546-1718, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
We have extended our analysis of the role of the long arm of the X chromosome (Xq28) in sexual orientation by DNA linkage analyses of two newly ascertained series of families that contained either two gay brothers or two lesbian sisters as well as heterosexual siblings. Linkage between the Xq28 markers and sexual orientation was detected for the gay male families but not for the lesbian families or for families that failed to meet defined inclusion criteria for the study of sex–linked sexual orientation. Our results corroborate the previously reported linkage between Xq28 and male homosexuality in selected kinships and suggest that this region contains a locus t...
Subjects
Medical Subject Headings: behavior and behavior mechanismscongenital, hereditary, and neonatal diseases and abnormalitiesreproductive and urinary physiology
free text keywords: Genetics, X chromosome, Gene mapping, Homosexuality, media_common.quotation_subject, media_common, Biology, Lesbian, Locus (genetics), Sexual orientation, Xq28, Chromosome
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