publication . Article . Other literature type . 2011

Functional diversification of the RING finger and other binuclear treble clef domains in prokaryotes and the early evolution of the ubiquitin system

L. Aravind; A. Maxwell Burroughs; Lakshminarayan M. Iyer;
Open Access
  • Published: 06 May 2011 Journal: Molecular BioSystems, volume 7, page 2,261 (issn: 1742-206X, eissn: 1742-2051, Copyright policy)
  • Publisher: Royal Society of Chemistry (RSC)
Abstract
Recent studies point to a diverse assemblage of prokaryotic cognates of the eukaryotic ubiquitin (Ub) system. These systems span an entire spectrum, ranging from those catalyzing cofactor and amino acid biosynthesis, with only adenylating E1-like enzymes and ubiquitin-like proteins (Ubls), to those that are closer to eukaryotic systems by virtue of possessing E2 enzymes. Until recently E3 enzymes were unknown in such prokaryotic systems. Using contextual information from comparative genomics, we uncover a diverse group of RING finger E3s in prokaryotes that are likely to function with E1s, E2s, JAB domain peptidases and Ubls. These E1s, E2s and RING fingers sugg...
Subjects
free text keywords: Biotechnology, Molecular Biology, Article, Ubiquitin, biology.protein, biology, LIM domain, Bioinformatics, Computational biology, Ring finger, medicine.anatomical_structure, medicine, Active site, Amino acid synthesis, chemistry.chemical_classification, chemistry, Clef, Comparative genomics, FYVE domain
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