publication . Article . 2002

Renewal of drug seeking by contextual cues after prolonged extinction in rats.

Hans S. Crombag; Yavin Shaham;
Open Access
  • Published: 01 Jan 2002
Abstract
Contextual stimuli associated with drug exposure can modulate various effects of drugs, but little is known about their role in relapse to drug seeking. Using a renewal procedure, the authors report that drug-associated contextual stimuli play a critical role in relapse to drug-seeking previously maintained by a heroin-cocaine mixture (speedball). Rats were trained to self-administer speedball, after which drug-reinforced behavior was extinguished over 20 days in the self-administration context or in a different context. On the test day, rats exposed to the drug-associated context, after extinction in a different context, reliably renewed drug seeking. The autho...
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free text keywords: Behavioral Neuroscience, Drug Abstinence, Developmental psychology, Stimulus (physiology), Drug seeking, Speedball, medicine.drug, medicine, Drug usage, Drug, media_common.quotation_subject, media_common, Psychology, Contextual Associations, Test day
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