publication . Article . 2021

The Past, Present, and Future of Breast Cancer Models for Nanomedicine Development

Paz Boix-Montesinos; Paula M. Soriano-Teruel; Ana Armiñán; Mar Orzáez; María J. Vicent;
Open Access
  • Published: 31 Mar 2021
Abstract
Graphical abstract
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ACM Computing Classification System: ComputingMethodologies_COMPUTERGRAPHICS
free text keywords: Pharmaceutical Science, Article, Breast cancer, Metastasis, Pre-clinical models, Nanomedicines, Organoids, Patient-derived xenografts, Animal models, Biomarkers, 2D, Two-dimensional, 3D, Three-dimensional, AGM, Aminoglutethimide, ALOX5, Arachidonate 5-lipoxygenase, ATM, Ataxia-telangiectasia mutated, AuNR, Gold nanorod, BRCA1, Breast cancer type 1 susceptibility protein, BRCA2, Breast cancer type 2 susceptibility protein, CAF, Cancer-associated fibroblasts, CCPM, Core-crosslinked block copolymer micelle, CDX, Cell-derived xenograft, CHEK2, Checkpoint kinase 2, CSC, Cancer stem cells, DC, Dendritic cells, DMBA, 7,12-dimethylbenzantracene, DOX, Doxorubicin, ECM, Extracellular matrix, EGFR, Epithelial growth factor receptor, EPR, Enhanced permeability and retention, ER, Estrogen receptor, ERS1, Estrogen receptor gene, FA, Folic acid, FDA, Food and Drug Administration, FITC, Fluorescein isothiocyanate, GEMM, Genetically modified mouse model, GSH, Glutathione, HER2, Epidermal growth factor receptor 2, HIF1α, Hypoxia-inducible factor 1 alpha, HPMA, Hydroxypropyl methacrylamide, ICAM1, Intercellular adhesion molecule–1, IHC, Immunohistochemistry, IO, Iron oxide, IONP, Iron oxide nanoparticle, iPSC, induced pluripotent stem cells, LTR, Long terminal repeat, MDR1, Multidrug resistance protein 1, MEF, Mouse embryonic fibroblasts, MMDOX, Doxorubicin-loaded mixed micelles, MMP, Metallopeptidases, MMTV, Mouse mammary tumor virus, MUC1, Mucin 1, NF1, Neurofibromin 1, NIR, Near-infrared, NK, Natural killer, NMU, N-methyl-n-nitrosourea, NOD-SCID, non-obese diabetic-severe combined immunodeficient, NOG, NOD/Shi-scid/γc−/− null, NP, Nanoparticle, NSG, NOD scid gamma, Nude, Athymic nude, PALB2, Partner and localizer of BRCA2, pDNA, Plasmid desoxyribonucleic acid, PDNA, Plasmid DNA, PDOX, Patient-derived organoid-derived xenograft, PDX, Patient-derived xenograft, PEG, Polyethylene glycol, PGA, Poly-L-glutamic acid, PI3KCA, Phosphatidylinositol 3-kinase, PIMs, Porcine pulmonary intravascular macrophages, PLA, Poly(lactide), PLGA, poly(lactide-co-glycolide), PPTT, Plasmonic photothermal therapy, PR, Progesterone receptor, PTBPC, Poly(2‐((tert‐butoxycarbonyl)amino)‐3‐propyl carbonate, PTEN, Phosphatase and tensin homolog, PyMT, Polyoma middle tumor-antigen, QbD, Quality by design, RAG, Rag-deficient, ROS, Reactive oxygen species, SCID, Severe combined immunodeficient, SPIO, Superparamagnetic iron oxide nanoparticle, SSMM, Sterically-stabilized mixed phospholipid nanomicelle, STK11, Serine/Threonine Kinase 11, TAM, Tumor-associated macrophages, Th1, Type 1 T helper, Th2, Type 2 T helper, TME, Tumor microenvironment, TNBC, Triple negative breast cancer, TP53, tumor protein p53, TPGS, D-α-tocopheryl polyethylene glycol 1000 succinate, uPAR, Urokinase plasminogen activator receptor, VIP, Vasoactive intestinal peptide, WAP, Whey acidic protein, WHO, World Health Organization
Funded by
EC| MyNano
Project
MyNano
Towards the design of Personalised Polymer-based Combination Nanomedicines for Advanced Stage Breast Cancer Patients
  • Funder: European Commission (EC)
  • Project Code: 648831
  • Funding stream: H2020 | ERC | ERC-COG
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Article . 2021
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