Radiolabeled Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitors: (Radio)Syntheses and in Vitro and First in Vivo Evaluation.

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Hugenberg, Verena; Wagner, Stefan; Kopka, Klaus; Schäfers, Michael; Schuit, Robert C.; Windhorst, Albert D.; Hermann, Sven;
(2017)
  • Related identifiers: doi: 10.1021/acs.jmedchem.6b01284
  • Subject: Drug Discovery | radiotracer | Selective matrix metalloproteinase inhibitors | Molecular Medicine | positron emission tomography | selective MMP-13 inhibitors

The noninvasive imaging of MMP activity in vivo could have a high impact in basic research as well as in clinical applications. This approach can be established using radiolabeled MMP inhibitors (MMPIs) as tracers for the detection of activated MMPs by means of PET. How... View more
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