publication . Other literature type . Article . 1997

AIB1, a Steroid Receptor Coactivator Amplified in Breast and Ovarian Cancer

Anzick S L; Kononen J; Walker R L; Azorsa D O; Tanner M M; Guan X Y; Sauter G; Kallioniemi O P; Trent J M; Meltzer P S;
  • Published: 15 Aug 1997
  • Publisher: American Association for the Advancement of Science (AAAS)
Abstract
Members of the recently recognized SRC-1 family of transcriptional coactivators interact with steroid hormone receptors to enhance ligand-dependent transcription. AIB1, a member of the SRC-1 family, was cloned during a search on the long arm of chromosome 20 for genes whose expression and copy number were elevated in human breast cancers. AIB1 amplification and overexpression were observed in four of five estrogen receptor–positive breast and ovarian cancer cell lines. Subsequent evaluation of 105 unselected specimens of primary breast cancer found AIB1 amplification in approximately 10 percent and high expression in 64 percent of the primary tumors analyzed. AI...
Subjects
free text keywords: Multidisciplinary, Estrogen receptor, Nuclear receptor, Breast cancer, medicine.disease, medicine, Biology, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Nuclear receptor coactivator 2, Steroid hormone, medicine.medical_treatment, Coactivator, Cancer research
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Abstract
Members of the recently recognized SRC-1 family of transcriptional coactivators interact with steroid hormone receptors to enhance ligand-dependent transcription. AIB1, a member of the SRC-1 family, was cloned during a search on the long arm of chromosome 20 for genes whose expression and copy number were elevated in human breast cancers. AIB1 amplification and overexpression were observed in four of five estrogen receptor–positive breast and ovarian cancer cell lines. Subsequent evaluation of 105 unselected specimens of primary breast cancer found AIB1 amplification in approximately 10 percent and high expression in 64 percent of the primary tumors analyzed. AI...
Subjects
free text keywords: Multidisciplinary, Estrogen receptor, Nuclear receptor, Breast cancer, medicine.disease, medicine, Biology, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Nuclear receptor coactivator 2, Steroid hormone, medicine.medical_treatment, Coactivator, Cancer research
Related Organizations
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