publication . Article . 2008

Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: Possible protective effects and therapeutic applications of bilirubin

Libor Vitek; Harvey A. Schwertner;
Open Access
  • Published: 01 May 2008 Journal: Atherosclerosis, volume 198, pages 1-11 (issn: 0021-9150, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Serum bilirubin has been shown to be inversely related to cardiovascular disease (CVD) in both retrospective and prospective studies. Meta-analysis of existing studies has also confirmed that serum bilirubin concentrations are inversely related to CVD. Less information is known about the protective effects of slightly elevated serum bilirubin concentrations. In this review, we will focus primarily on the association of serum bilirubin and CVD and the possible protective roles of bilirubin, heme oxygenase (HO), and bilirubin UDP-glucuronosyltransferase (UGT1A1). HO and biliverdin reductase control the formation of bilirubin, whereas UGT1A1 controls bilirubin conj...
Subjects
free text keywords: Cardiology and Cardiovascular Medicine, Endocrinology, medicine.medical_specialty, medicine, Oxidative stress, medicine.disease_cause, UGT1A1*28 Allele, Vascular disease, medicine.disease, Biliverdin reductase, Heme oxygenase, Prospective cohort study, business.industry, business, Gilbert Syndrome, Bilirubin, chemistry.chemical_compound, chemistry, Internal medicine
Related Organizations
Abstract
Serum bilirubin has been shown to be inversely related to cardiovascular disease (CVD) in both retrospective and prospective studies. Meta-analysis of existing studies has also confirmed that serum bilirubin concentrations are inversely related to CVD. Less information is known about the protective effects of slightly elevated serum bilirubin concentrations. In this review, we will focus primarily on the association of serum bilirubin and CVD and the possible protective roles of bilirubin, heme oxygenase (HO), and bilirubin UDP-glucuronosyltransferase (UGT1A1). HO and biliverdin reductase control the formation of bilirubin, whereas UGT1A1 controls bilirubin conj...
Subjects
free text keywords: Cardiology and Cardiovascular Medicine, Endocrinology, medicine.medical_specialty, medicine, Oxidative stress, medicine.disease_cause, UGT1A1*28 Allele, Vascular disease, medicine.disease, Biliverdin reductase, Heme oxygenase, Prospective cohort study, business.industry, business, Gilbert Syndrome, Bilirubin, chemistry.chemical_compound, chemistry, Internal medicine
Related Organizations
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