publication . Article . 2016

In vivo evidence of a functional association between immune cells in blood and brain in healthy human subjects.

Naoki Kanegawa; Karin Collste; Anton Forsberg; Martin Schain; Ryosuke Arakawa; Aurelija Jucaite; Mats Lekander; Caroline Olgart Höglund; Eva Kosek; Jon Lampa; ...
Open Access
  • Published: 25 Jan 2016 Journal: Brain, Behavior, and Immunity, volume 54, pages 149-157 (issn: 0889-1591, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Microglia, the resident macrophages in the central nervous system, are thought to be maintained by a local self-renewal mechanism. Although preclinical and in vitro studies have suggested that the brain may contain immune cells also from peripheral origin, the functional association between immune cells in the periphery and brain at physiological conditions is poorly understood. We examined 32 healthy individuals using positron emission tomography (PET) and [(11)C]PBR28, a radioligand for the 18-kDa translocator protein (TSPO) which is expressed both in brain microglia and blood immune cells. In 26 individuals, two measurements were performed with varying time i...
Subjects
free text keywords: PET, [11C]PBR28, Blood immune cells, Immunology, Behavioral Neuroscience, Endocrine and Autonomic Systems, Endocrinology, medicine.medical_specialty, medicine, In vitro, Translocator protein, biology.protein, biology, In vivo, Immune system, Microglia, medicine.anatomical_structure, Internal medicine, Blood–brain barrier, Radioligand, Central nervous system
Funded by
EC| INMIND
Project
INMIND
Imaging of Neuroinflammation in Neurodegenerative Diseases
  • Funder: European Commission (EC)
  • Project Code: 278850
  • Funding stream: FP7 | SP1 | HEALTH
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publication . Article . 2016

In vivo evidence of a functional association between immune cells in blood and brain in healthy human subjects.

Naoki Kanegawa; Karin Collste; Anton Forsberg; Martin Schain; Ryosuke Arakawa; Aurelija Jucaite; Mats Lekander; Caroline Olgart Höglund; Eva Kosek; Jon Lampa; ...