publication . Article . 1994

CLONING AND ANALYSIS OF MAGE-1-RELATED GENES

M. Ding; R.J. Beck; C.J. Keller; R.G. Fenton;
Open Access
  • Published: 01 Jul 1994
Abstract
Abstract The spectrum of MAGE gene expression in the human melanoma cell line DM150 was examined using reverse transcription polymerase chain reaction and cDNA cloning. We have examined isolated five full-length cDNAs from DM150 which were identified as MAGE-1, MAGE-3, MAGE-12 and two previously undescribed MAGE, MAGE-3b and MAGE-X2. DNA sequence analysis of the coding regions of the MAGE-3b and MAGE-X2 genes revealed 83% and 88% identity with MAGE-1, while MAGE-3b was 98% homologous with the full length MAGE-3 clone. The predicted amino acid sequences of MAGE-X2 and MAGE-3b contain consensus HLA-A1 peptide binding motifs, suggesting that, like MAGE-1, they may ...
Subjects
Medical Subject Headings: endocrine systemneoplasms
free text keywords: Biophysics, Cell Biology, Biochemistry, Molecular Biology, Peptide binding, Gene, Coding region, Gene expression, Cloning, Genetics, Peptide sequence, Biology, Primer (molecular biology), Sequence analysis
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publication . Article . 1994

CLONING AND ANALYSIS OF MAGE-1-RELATED GENES

M. Ding; R.J. Beck; C.J. Keller; R.G. Fenton;