Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity

Article, Other literature type OPEN
Kumar, Abhishek; Ouyang, Mingxing; Van den Dries, Koen; McGhee, Ewan James; Tanaka, Keiichiro; Anderson, Marie D.; Groisman, Alexander; Goult, Benjamin T.; Anderson, Kurt I.; Schwartz, Martin A.;
  • Publisher: The Rockefeller University Press
  • Journal: volume 213,issue 3,pages371-383issn: 0021-9525, eissn: 1540-8140
  • Related identifiers: pmc: PMC4862330, doi: 10.1083/jcb.201510012
  • Subject: Research Articles | Article
    mesheuropmc: embryonic structures | macromolecular substances | animal structures

Integrin-dependent adhesions are mechanosensitive structures in which talin mediates a linkage to actin filaments either directly or indirectly by recruiting vinculin. Here, we report the development and validation of a talin tension sensor. We find that talin in focal ... View more
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