publication . Article . 2018

Metabolomics facilitates the discrimination of the specific anti-cancer effects of free- and polymer-conjugated doxorubicin in breast cancer models

Ana Armiñán; Martina Palomino-Schätzlein; Coralie Deladriere; Juan J. Arroyo-Crespo; Sonia Vicente-Ruiz; María J. Vicent; Antonio Pineda-Lucena;
Open Access English
  • Published: 08 Feb 2018 Journal: Biomaterials, volume 162, pages 144-153 (issn: 01429612, Copyright policy)
Abstract
Metabolomics is becoming a relevant tool for understanding the molecular mechanisms involved in the response to new drug delivery systems. The applicability of this experimental approach to cell cultures and animal models makes metabolomics a useful tool for establishing direct connections between in vitro and in vivo data, thus providing a reliable platform for the characterization of chemotherapeutic agents. Herein, we used metabolomic profiles based on nuclear magnetic resonance (NMR) spectroscopy to evaluate the biochemical pathways involved in the response to a chemotherapeutic anthracycline drug (Doxorubicin, Dox) and an N-(2- hydroxypropyl) methacrylamide...
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free text keywords: metabolomics, NMR, nanomedicine, polymer therapeutics, breast cancer, Biophysics, Mechanics of Materials, Bioengineering, Biomaterials, Ceramics and Composites, Drug, media_common.quotation_subject, media_common, Anthracycline, Cancer research, Metabolomics, Flow cytometry, medicine.diagnostic_test, medicine, Cancer, medicine.disease, Drug delivery, Cell culture, Doxorubicin, medicine.drug, Chemistry
Funded by
EC| MyNano
Project
MyNano
Towards the design of Personalised Polymer-based Combination Nanomedicines for Advanced Stage Breast Cancer Patients
  • Funder: European Commission (EC)
  • Project Code: 648831
  • Funding stream: H2020 | ERC | ERC-COG
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