publication . Article . Other literature type . 2014

Body Fluid Cytokine Levels in Mild Cognitive Impairment and Alzheimer’s Disease: a Comparative Overview

Markus P. Kummer; Marius Krauthausen; Frederic Brosseron; Michael T. Heneka; Michael T. Heneka;
Open Access English
  • Published: 25 Feb 2014 Journal: Molecular Neurobiology, volume 50, issue 0893-7648, pages 534-544 (issn: 0893-7648, eissn: 1559-1182, Copyright policy)
  • Publisher: Springer US
Abstract
This article gives a comprehensive overview of cytokine and other inflammation associated protein levels in plasma, serum and cerebrospinal fluid (CSF) of patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI). We reviewed 118 research articles published between 1989 and 2013 to compare the reported levels of 66 cytokines and other proteins related to regulation and signaling in inflammation in the blood or CSF obtained from MCI and AD patients. Several cytokines are evidently regulated in (neuro-) inflammatory processes associated with neurodegenerative disorders. Others do not display changes in the blood or CSF during disease progression. ...
Subjects
free text keywords: Alzheimer’s disease, Neuroinflammation, Cerebrospinal fluid, Cytokines, Mild cognitive impairment, Serum, Article, Cellular and Molecular Neuroscience, Inflammation, medicine.symptom, medicine, business.industry, business, Disease, Neurology, medicine.medical_specialty, Immunology, Alzheimer's disease, medicine.disease, Cytokine, medicine.medical_treatment, Neurodegeneration, Tumor necrosis factor alpha
Related Organizations
Funded by
EC| INMIND
Project
INMIND
Imaging of Neuroinflammation in Neurodegenerative Diseases
  • Funder: European Commission (EC)
  • Project Code: 278850
  • Funding stream: FP7 | SP1 | HEALTH
Download fromView all 7 versions
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Article . 2014
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Article . 2014
Provider: ZENODO
142 references, page 1 of 10

Dinarello, CA. Historical insights into cytokines. Eur J Immunol. 2007; 37 (Suppl 1): S34-S45 [OpenAIRE] [PubMed]

Rao, JS. Neuroinflammation and synaptic loss. Neurochem Res. 2012; 37 (5): 903-910 [OpenAIRE] [PubMed]

Tarkowski, E. Intrathecal inflammation precedes development of Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2003; 74 (9): 1200-1205 [OpenAIRE] [PubMed]

Lee, KS. Peripheral cytokines and chemokines in Alzheimer’s disease. Dement Geriatr Cogn Disord. 2009; 28 (4): 281-287 [PubMed]

Swardfager, W. A meta-analysis of cytokines in Alzheimer’s disease. Biol Psychiatry. 2010; 68 (10): 930-941 [OpenAIRE] [PubMed]

Inadera, H. Increase in circulating levels of monocyte chemoattractant protein-1 with aging. J Interferon Cytokine Res. 1999; 19 (10): 1179-1182 [PubMed]

Bruunsgaard, H. Elevated levels of tumor necrosis factor alpha and mortality in centenarians. Am J Med. 2003; 115 (4): 278-283 [OpenAIRE] [PubMed]

Kiecolt-Glaser, JK. Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proc Natl Acad Sci U S A. 2003; 100 (15): 9090-9095 [OpenAIRE] [PubMed]

Kale, SS, Yende, S. Effects of aging on inflammation and hemostasis through the continuum of critical illness. Aging Dis. 2011; 2 (6): 501-511 [OpenAIRE] [PubMed]

Perry, VH. Contribution of systemic inflammation to chronic neurodegeneration. Acta Neuropathol. 2010; 120 (3): 277-286 [PubMed]

Jackson, JC. The association between delirium and cognitive decline: a review of the empirical literature. Neuropsychol Rev. 2004; 14 (2): 87-98 [PubMed]

Blennow, K, de Leon, MJ, Zetterberg, H. Alzheimer’s disease. Lancet. 2006; 368 (9533): 387-403 [PubMed]

Bettcher, BM, Kramer, JH. Inflammation and clinical presentation in neurodegenerative disease: a volatile relationship. Neurocase. 2012; 19 (2): 182-200 [OpenAIRE] [PubMed]

McKhann, G. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer’s disease. Neurology. 1984; 34 (7): 939-944 [PubMed]

Folstein, MF, Folstein, SE, McHugh, PR. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12 (3): 189-198 [OpenAIRE] [PubMed]

142 references, page 1 of 10
Abstract
This article gives a comprehensive overview of cytokine and other inflammation associated protein levels in plasma, serum and cerebrospinal fluid (CSF) of patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI). We reviewed 118 research articles published between 1989 and 2013 to compare the reported levels of 66 cytokines and other proteins related to regulation and signaling in inflammation in the blood or CSF obtained from MCI and AD patients. Several cytokines are evidently regulated in (neuro-) inflammatory processes associated with neurodegenerative disorders. Others do not display changes in the blood or CSF during disease progression. ...
Subjects
free text keywords: Alzheimer’s disease, Neuroinflammation, Cerebrospinal fluid, Cytokines, Mild cognitive impairment, Serum, Article, Cellular and Molecular Neuroscience, Inflammation, medicine.symptom, medicine, business.industry, business, Disease, Neurology, medicine.medical_specialty, Immunology, Alzheimer's disease, medicine.disease, Cytokine, medicine.medical_treatment, Neurodegeneration, Tumor necrosis factor alpha
Related Organizations
Funded by
EC| INMIND
Project
INMIND
Imaging of Neuroinflammation in Neurodegenerative Diseases
  • Funder: European Commission (EC)
  • Project Code: 278850
  • Funding stream: FP7 | SP1 | HEALTH
Download fromView all 7 versions
OpenAIRE
Article . 2014
Provider: OpenAIRE
ZENODO
Article . 2014
Provider: ZENODO
142 references, page 1 of 10

Dinarello, CA. Historical insights into cytokines. Eur J Immunol. 2007; 37 (Suppl 1): S34-S45 [OpenAIRE] [PubMed]

Rao, JS. Neuroinflammation and synaptic loss. Neurochem Res. 2012; 37 (5): 903-910 [OpenAIRE] [PubMed]

Tarkowski, E. Intrathecal inflammation precedes development of Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2003; 74 (9): 1200-1205 [OpenAIRE] [PubMed]

Lee, KS. Peripheral cytokines and chemokines in Alzheimer’s disease. Dement Geriatr Cogn Disord. 2009; 28 (4): 281-287 [PubMed]

Swardfager, W. A meta-analysis of cytokines in Alzheimer’s disease. Biol Psychiatry. 2010; 68 (10): 930-941 [OpenAIRE] [PubMed]

Inadera, H. Increase in circulating levels of monocyte chemoattractant protein-1 with aging. J Interferon Cytokine Res. 1999; 19 (10): 1179-1182 [PubMed]

Bruunsgaard, H. Elevated levels of tumor necrosis factor alpha and mortality in centenarians. Am J Med. 2003; 115 (4): 278-283 [OpenAIRE] [PubMed]

Kiecolt-Glaser, JK. Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proc Natl Acad Sci U S A. 2003; 100 (15): 9090-9095 [OpenAIRE] [PubMed]

Kale, SS, Yende, S. Effects of aging on inflammation and hemostasis through the continuum of critical illness. Aging Dis. 2011; 2 (6): 501-511 [OpenAIRE] [PubMed]

Perry, VH. Contribution of systemic inflammation to chronic neurodegeneration. Acta Neuropathol. 2010; 120 (3): 277-286 [PubMed]

Jackson, JC. The association between delirium and cognitive decline: a review of the empirical literature. Neuropsychol Rev. 2004; 14 (2): 87-98 [PubMed]

Blennow, K, de Leon, MJ, Zetterberg, H. Alzheimer’s disease. Lancet. 2006; 368 (9533): 387-403 [PubMed]

Bettcher, BM, Kramer, JH. Inflammation and clinical presentation in neurodegenerative disease: a volatile relationship. Neurocase. 2012; 19 (2): 182-200 [OpenAIRE] [PubMed]

McKhann, G. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer’s disease. Neurology. 1984; 34 (7): 939-944 [PubMed]

Folstein, MF, Folstein, SE, McHugh, PR. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12 (3): 189-198 [OpenAIRE] [PubMed]

142 references, page 1 of 10
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